PF3D7_0313000

Genome location: Pf3D7_03_v3:537,355..538,827(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.40	0.81
Trophozoite	possibly expressed	0.38	0.77
Schizont	expressed	0.29	0.80
Gametocyte	not expressed	0.51	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -1.935 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77363

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145725

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	10	6	10
disruptive	16	52	22	58
missense	9	43	18	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	18	11	12
disruptive	30	108	32	75
missense	18	80	23	43

PlasmoDB Total SNPs: 121

Non-coding: 54 | Synonymous: 20 | Nonsynonymous: 46 | Stop Codon: 1

Protein Information

Protein Length: 346 | Molecular Weight (kDa): 40.583

UniProt ID(s): O77363

PDB ID(s): None

Isoelectric Point: 4.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095