About Gene List

PF3D7_0313200

Genome location: Pf3D7_03_v3:543,010..543,942(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.04 0.98
Trophozoite expressed 0.22 0.85
Schizont possibly expressed 0.07 0.95
Gametocyte expressed 0.35 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.372 | MFS: -2.587 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0410900)

Modification: Mutated | RMgm-4737

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77340

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139430

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 4 4 14
disruptive 0 23 7 26
missense 0 23 7 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 17 10 15
disruptive 11 41 23 50
missense 6 33 23 40

PlasmoDB Total SNPs: 38

Non-coding: 21 | Synonymous: 10 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 233 | Molecular Weight (kDa): 28.427

UniProt ID(s): O77340

PDB ID(s): None

Isoelectric Point: 6.84

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
26292257 Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. Aguiar JC, Bolton J, ..., Richie TL 10.1371/journal.pone.0136109
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895