About Gene List

PF3D7_0313300

Genome location: Pf3D7_03_v3:544,055..545,227(-)

Genome classification: Core

Function and Localization

Product Description: YGGT family protein, putative

SignalP Peptide: MPFLLFSFFLFFLLINQ

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.01 1.00
Trophozoite no data 0.06 0.96
Schizont no data 0.01 0.99
Gametocyte no data 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.133 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H470

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158652

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 8 7 6
disruptive 2 14 10 20
missense 2 11 9 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 16 5 13
disruptive 7 35 15 34
missense 5 26 13 24

PlasmoDB Total SNPs: 84

Non-coding: 72 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 187 | Molecular Weight (kDa): 22.04

UniProt ID(s): C0H470

PDB ID(s): None

Isoelectric Point: 10.95

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003425 CCB3/YggT
PFam PF02325 CCB3/YggT
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895