About Gene List

PF3D7_0313400

Genome location: Pf3D7_03_v3:545,589..548,500(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.64 0.72
Trophozoite expressed 0.61 0.68
Schizont expressed 0.12 0.93
Gametocyte expressed 1.27 0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313400

Resistome Missense Mutations: Q365K, Q370K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.155 | MFS: -2.815 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77339

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533680

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 24 11 37
disruptive 97 164 77 176
missense 48 89 56 118

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 50 25 46
disruptive 151 304 120 210
missense 64 185 84 127

PlasmoDB Total SNPs: 273

Non-coding: 86 | Synonymous: 96 | Nonsynonymous: 91 | Stop Codon: 0

Protein Information

Protein Length: 784 | Molecular Weight (kDa): 94.884

UniProt ID(s): O77339

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104