About Gene List

PF3D7_0313500 (PfG)

Genome location: Pf3D7_03_v3:548,576..551,854(+)

Genome classification: Core

Function and Localization

Product Description: Ras-like G protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0005829 cytosol
Function GO:0003924 GTPase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.16 0.92
Trophozoite expressed 0.33 0.80
Schizont expressed 0.06 0.96
Gametocyte expressed 0.23 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.123 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A0P0ZF19

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532341

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 34 23 53
disruptive 69 105 70 142
missense 40 74 64 107

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 69 35 53
disruptive 106 198 101 209
missense 55 152 76 143

PlasmoDB Total SNPs: 201

Non-coding: 91 | Synonymous: 48 | Nonsynonymous: 62 | Stop Codon: 0

Protein Information

Protein Length: 911 | Molecular Weight (kDa): 108.564

UniProt ID(s): A0A0P0ZF19, O77338

PDB ID(s): None

Isoelectric Point: 8.65

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005225 Small GTP-binding protein domain
InterPro IPR006073 GTP binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR032859 GTPase Der, C-terminal KH-domain-like
PFam PF01926 GTP binding domain
PFam PF14714 GTPase Der, C-terminal KH-domain-like
Superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolase

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
26540393 A Putative Non-Canonical Ras-Like GTPase from P. falciparum: Chemical Propertiesand Characterization of the Protein. Kaiser A, Langer B, ..., Kruger M 10.1371/journal.pone.0140994
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g
38252559 Coordinated regulation of gene expression in Plasmodium female gametocytes by twotranscription factors Murata Y, Nishi T, ..., Yuda M 10.7554/eLife.88317