PF3D7_0313600

Genome location: Pf3D7_03_v3:551,348..554,770(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	expressed	0.20	0.87
Schizont	expressed	0.10	0.93
Gametocyte	expressed	1.37	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.814 | MFS: -2.108 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77337

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532857

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	22	8	23
disruptive	153	137	50	102
missense	59	36	31	52

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	37	13	37
disruptive	192	189	89	140
missense	64	72	53	67

PlasmoDB Total SNPs: 360

Non-coding: 156 | Synonymous: 68 | Nonsynonymous: 135 | Stop Codon: 1

Protein Information

Protein Length: 594 | Molecular Weight (kDa): 70.716

UniProt ID(s): O77337

PDB ID(s): None

Isoelectric Point: 6.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095