About Gene List

PF3D7_0313800

Genome location: Pf3D7_03_v3:559,025..563,280(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.15 0.93
Trophozoite possibly expressed 1.17 0.43
Schizont possibly expressed 0.34 0.81
Gametocyte not expressed 0.79 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.084 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H472

"Best" AlphaFill ligand hit: 1YJ (n-[4-({[(6r)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid, Local RMSD=0.24) with 5UIL (Global RMSD=15.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532481

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 21 12 32
disruptive 9 50 34 94
missense 6 48 31 70

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 44 23 33
disruptive 24 133 77 166
missense 15 98 56 118

PlasmoDB Total SNPs: 206

Non-coding: 173 | Synonymous: 21 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 661 | Molecular Weight (kDa): 79.922

UniProt ID(s): C0H472, Q689C0

PDB ID(s): None

Isoelectric Point: 8.63

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895