About Gene List

PF3D7_0313900

Genome location: Pf3D7_03_v3:562,366..565,656(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite not expressed 0.11 0.93
Schizont not expressed 0.06 0.96
Gametocyte expressed 0.62 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0313900

Resistome Missense Mutations: Q947K

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.457 | #Insertions: 7

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0411600)

  • Relative Growth Rate: 0.96 ± 0.17
  • Confidence: 4.93

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0411600)

Modification: Disrupted | RMgm-1895

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97257

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532887

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 45 35 58
disruptive 53 134 73 156
missense 42 105 59 123

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 87 46 84
disruptive 100 285 118 319
missense 68 197 96 187

PlasmoDB Total SNPs: 131

Non-coding: 0 | Synonymous: 68 | Nonsynonymous: 63 | Stop Codon: 0

Protein Information

Protein Length: 1096 | Molecular Weight (kDa): 134.369

UniProt ID(s): O97257

PDB ID(s): None

Isoelectric Point: 9.56

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895