About Gene List

PF3D7_0314000

Genome location: Pf3D7_03_v3:567,002..569,084(+)

Genome classification: Core

Function and Localization

Product Description: HSP20-like chaperone, putative

SignalP Peptide: MFFFCFFVFCIFLFFNVVLS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005829 cytosol
Component GO:0005634 nucleus
Function GO:0051879 Hsp90 protein binding
Function GO:0051087 chaperone binding
Process GO:0051131 chaperone-mediated protein complex assembly
Process GO:0032780 negative regulation of ATP-dependent activity
Process GO:0006457 protein folding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.04 0.98
Trophozoite expressed 0.32 0.80
Schizont expressed 0.52 0.70
Gametocyte expressed 0.61 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0314000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.682 | MFS: -2.312 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0411700)

  • Relative Growth Rate: 0.95 ± 0.09
  • Confidence: 6.25

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0411700)

Modification: Disrupted | RMgm-1896

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H473

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_118417

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 12 4 18
disruptive 1 11 10 19
missense 1 11 6 15

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 27 16 11
disruptive 11 41 27 71
missense 3 27 16 58

PlasmoDB Total SNPs: 103

Non-coding: 93 | Synonymous: 10 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 275 | Molecular Weight (kDa): 32.611

UniProt ID(s): C0H473

PDB ID(s): None

Isoelectric Point: 4.86

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008978 HSP20-like chaperone
PFam N/A N/A
Superfamily SSF49764 HSP20-like chaperone

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095