Product Description: vesicle transport v-SNARE protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0031201 | SNARE complex |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0031902 | late endosome membrane |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006896 | Golgi to vacuole transport |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Process | GO:0006623 | protein targeting to vacuole |
| Process | GO:0042147 | retrograde transport, endosome to Golgi |
| Process | GO:0048280 | vesicle fusion with Golgi apparatus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | nd | nd |
| Trophozoite | possibly expressed | nd | nd |
| Schizont | possibly expressed | nd | nd |
| Gametocyte | possibly expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0314100.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.94 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1450600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZX23
"Best" AlphaFill ligand hit: DTU ((2r,3s)-1,4-dimercaptobutane-2,3-diol, Local RMSD=2.23) with 4DLX (Global RMSD=25.06)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101479
Most Similar Human Ortholog: Q96AJ9
TM-align score: 0.63 | RMSD: 2.55
Seq Identity: 0.08 | Length: 66 / 198
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151532 | vesicle transport through interaction with t-SNAREs 1A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 9 | 6 | 8 |
| disruptive | 5 | 6 | 4 | 16 |
| missense | 4 | 6 | 4 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 6 | 15 |
| disruptive | 6 | 23 | 11 | 37 |
| missense | 4 | 22 | 11 | 19 |
PlasmoDB Total SNPs: 54
Non-coding: 47 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 198 | Molecular Weight (kDa): 23.774
UniProt ID(s): A0A143ZX23
PDB ID(s): None
Isoelectric Point: 9.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007705 | Vesicle transport v-SNARE, N-terminal |
| InterPro | IPR010989 | SNARE |
| PFam | PF05008 | Vesicle transport v-SNARE, N-terminal |
| Superfamily | SSF47661 | SNARE |
| Superfamily | SSF58038 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |