Product Description: DER1-like protein
SignalP Peptide: MLFYKLICLFLSFIIIIIHG
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex |
| Component | GO:0020011 | apicoplast |
| Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0051787 | misfolded protein binding |
| Function | GO:1990381 | ubiquitin-specific protease binding |
| Process | GO:0030968 | endoplasmic reticulum unfolded protein response |
| Process | GO:0010564 | regulation of cell cycle process |
| Process | GO:0030433 | ubiquitin-dependent ERAD pathway |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.86 | 0.54 |
| Schizont | expressed | 0.22 | 0.87 |
| Gametocyte | not expressed | 0.37 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0314300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.141 | MFS: -3.281 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1006200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97275
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 18 | 5 | 21 |
| disruptive | 3 | 27 | 13 | 50 |
| missense | 2 | 27 | 12 | 40 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 31 | 12 | 23 |
| disruptive | 14 | 59 | 30 | 106 |
| missense | 8 | 50 | 23 | 69 |
PlasmoDB Total SNPs: 87
Non-coding: 59 | Synonymous: 23 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 452 | Molecular Weight (kDa): 55.219
UniProt ID(s): O97275
PDB ID(s): None
Isoelectric Point: 10.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007599 | Derlin |
| PFam | PF04511 | Derlin |
| Superfamily | SSF144091 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19502583 | An unusual ERAD-like complex is targeted to the apicoplast of Plasmodiumfalciparum. | Spork S, Hiss JA, ..., Przyborski JM | 10.1128/EC.00083-09 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 8631297 | Der1, a novel protein specifically required for endoplasmic reticulum degradationin yeast | Knop M, Finger A, ..., Wolf DH | https://pubmed.ncbi.nlm.nih.gov/8631297/ |