About Gene List

PF3D7_0314600

Genome location: Pf3D7_03_v3:586,077..588,321(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.38 0.82
Trophozoite possibly expressed 0.50 0.72
Schizont not expressed 0.29 0.82
Gametocyte not expressed 0.40 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0314600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.404 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9Y011

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.02) with 2BVL (Global RMSD=22.41)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146171

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 12 5 13
disruptive 6 30 20 59
missense 6 19 14 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 21 10 8
disruptive 23 96 30 115
missense 11 60 19 62

PlasmoDB Total SNPs: 169

Non-coding: 130 | Synonymous: 16 | Nonsynonymous: 20 | Stop Codon: 3

Protein Information

Protein Length: 258 | Molecular Weight (kDa): 31.524

UniProt ID(s): Q9Y011

PDB ID(s): None

Isoelectric Point: 10.18

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095