About Gene List

PF3D7_0314700 (RNF1)

Genome location: Pf3D7_03_v3:588,362..594,166(-)

Genome classification: Core

Function and Localization

Product Description: RING finger protein RNF1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0042393 histone binding
Function GO:0061630 ubiquitin protein ligase activity
Process GO:0006511 ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite possibly expressed 0.03 0.98
Schizont possibly expressed 0.01 0.99
Gametocyte not expressed 0.53 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0314700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.196 | #Insertions: 7

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0412400)

  • Relative Growth Rate: 0.94 ± 0.06
  • Confidence: 7.17

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0412400)

Modification: Disrupted | RMgm-1898

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97260

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 59 32 55
disruptive 64 186 87 189
missense 31 104 68 141

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 105 39 81
disruptive 111 333 133 316
missense 47 227 101 184

PlasmoDB Total SNPs: 324

Non-coding: 172 | Synonymous: 91 | Nonsynonymous: 60 | Stop Codon: 1

Protein Information

Protein Length: 1181 | Molecular Weight (kDa): 135.638

UniProt ID(s): O97260

PDB ID(s): None

Isoelectric Point: 5.96

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001841 Zinc finger, RING-type
PFam PF13639 Zinc finger, RING-type
Superfamily SSF57850 N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
28791254 Transcriptional Profiling Defines Histone Acetylation as a Regulator of GeneExpression during Human-to-Mosquito Transmission of the Malaria ParasitePlasmodium falciparum. Ngwa CJ, Kiesow MJ, ..., Pradel G 10.3389/fcimb.2017.00320