PF3D7_0314800

Genome location: Pf3D7_03_v3:604,442..608,381(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.12	0.93
Schizont	possibly expressed	0.73	0.63
Gametocyte	expressed	0.14	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0314800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.971 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H475

"Best" AlphaFill ligand hit: M0E (moenomycin, Local RMSD=0.52) with 2OLV (Global RMSD=40.03)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532993

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	28	14	38
disruptive	35	114	66	167
missense	21	101	60	145

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	49	30	44
disruptive	63	266	103	248
missense	40	212	89	170

PlasmoDB Total SNPs: 136

Non-coding: 47 | Synonymous: 44 | Nonsynonymous: 43 | Stop Codon: 2

Protein Information

Protein Length: 1040 | Molecular Weight (kDa): 125.031

UniProt ID(s): C0H475

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095