About Gene List

PF3D7_0315000

Genome location: Pf3D7_03_v3:610,994..612,107(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0008270 zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite possibly expressed 0.27 0.83
Schizont not expressed 0.04 0.97
Gametocyte not expressed 0.35 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0315000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.608 | MFS: -2.548 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97265

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119455

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 7 3 10
disruptive 3 7 5 16
missense 3 7 5 12

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 15 3 13
disruptive 8 23 13 32
missense 4 14 7 21

PlasmoDB Total SNPs: 44

Non-coding: 37 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 189 | Molecular Weight (kDa): 22.474

UniProt ID(s): O97265

PDB ID(s): None

Isoelectric Point: 10.06

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007527 Zinc finger, SWIM-type
PFam PF04434 Zinc finger, SWIM-type
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095