Product Description: eukaryotic translation initiation factor 4E
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043186 | P granule |
| Component | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0000340 | RNA 7-methylguanosine cap binding |
| Function | GO:0000339 | RNA cap binding |
| Function | GO:0098808 | mRNA cap binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.26 | 0.86 |
| Trophozoite | expressed | 0.22 | 0.86 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | possibly expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0315100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.335 | MFS: -2.613 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97266
"Best" AlphaFill ligand hit: GTA (p1-7-methylguanosine-p3-adenosine-5',5'-triphosphate, Local RMSD=0.40) with 1IPB (Global RMSD=4.84)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P06730 | Eukaryotic translation initiation factor 4E | OrthoDB | US9073881, 109US9073881, 2US9073881, 3US9073881, 4... | |
| P29338 | Eukaryotic translation initiation factor 4E | Oryctolagus cuniculus | OrthoDB | CHEMBL3604542CHEMBL3604543CHEMBL1094973CHEMBL3604536... |
Ortholog Group (OrthoMCL): OG6_100627
Most Similar Human Ortholog: P06730
TM-align score: 0.71 | RMSD: 2.27
Seq Identity: 0.25 | Length: 171 / 227
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151247 | eukaryotic translation initiation factor 4E |
| ENSG00000175766 | eukaryotic translation initiation factor 4E family member 1B |
Protein Length: 227 | Molecular Weight (kDa): 26.948
PDB ID(s): None
Isoelectric Point: 8.4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001040 | Translation Initiation factor eIF- 4e |
| InterPro | IPR023398 | Translation Initiation factor eIF- 4e-like |
| PFam | PF01652 | Translation Initiation factor eIF- 4e |
| Superfamily | SSF55418 | Translation Initiation factor eIF- 4e-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 1 | 8 |
| disruptive | 0 | 1 | 2 | 13 |
| missense | 0 | 1 | 2 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 2 | 4 |
| disruptive | 0 | 14 | 7 | 35 |
| missense | 0 | 8 | 6 | 26 |
PlasmoDB Total SNPs: 69
Non-coding: 61 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17692399 | Characterization of human malaria parasite Plasmodium falciparum eIF4E homologueand mRNA 5' cap status. | Shaw PJ, Ponmee N, ..., Yuthavong Y | 10.1016/j.molbiopara.2007.07.003 |
| 19751846 | Isolation and functional characterization of eIF4F components and poly(A)-bindingprotein from Plasmodium falciparum. | Tuteja R, Pradhan A | 10.1016/j.parint.2009.09.001 |
| 20169188 | Universal features of post-transcriptional gene regulation are critical forPlasmodium zygote development. | Mair GR, Lasonder E, ..., Waters AP | 10.1371/journal.ppat.1000767 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |