Product Description: circumsporozoite- and TRAP-related protein
SignalP Peptide: MKKAFVLIFSCFLLFLPLHIVRT
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020009 | microneme |
| Function | GO:0034235 | GPI anchor binding |
| Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Process | GO:0002312 | B cell activation involved in immune response |
| Process | GO:0098609 | cell-cell adhesion |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.14 | 0.94 |
| Trophozoite | expressed | 0.04 | 0.98 |
| Schizont | expressed | 0.04 | 0.98 |
| Gametocyte | expressed | 0.19 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0315200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.068 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_0415800)
Modification: Disrupted | RMgm-5051
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97267
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 43 | 33 | 78 |
| disruptive | 48 | 73 | 43 | 117 |
| missense | 31 | 60 | 40 | 98 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 81 | 33 | 100 |
| disruptive | 60 | 144 | 82 | 209 |
| missense | 36 | 115 | 73 | 160 |
PlasmoDB Total SNPs: 127
Non-coding: 0 | Synonymous: 61 | Nonsynonymous: 66 | Stop Codon: 0
Protein Length: 2114 | Molecular Weight (kDa): 237.921
UniProt ID(s): O96930, O97267, Q25757
PDB ID(s): None
Isoelectric Point: 4.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| InterPro | IPR002035 | von Willebrand factor, type A |
| InterPro | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| InterPro | IPR036465 | von Willebrand factor A-like domain superfamily |
| PFam | PF00090 | Thrombospondin type-1 (TSP1) repeat |
| PFam | PF00092 | von Willebrand factor, type A |
| Superfamily | SSF53300 | von Willebrand factor A-like domain superfamily |
| Superfamily | SSF82895 | Thrombospondin type-1 (TSP1) repeat superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 10760158 | Developmental arrest of the human malaria parasite Plasmodium falciparum withinthe mosquito midgut via CTRP gene disruption. | Templeton TJ, Kaslow DC, Fidock DA | 10.1046/j.1365-2958.2000.01821.x |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19633296 | Structure of the Plasmodium falciparum circumsporozoite protein, a leadingmalaria vaccine candidate. | Plassmeyer ML, Reiter K, ..., Narum DL | 10.1074/jbc.M109.013706 |
| 33653360 | Genetic diversity and natural selection on the thrombospondin-related adhesiveprotein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guineaand global comparative analysis. | Lin LY, Huang HY, ..., Lin M | 10.1186/s12936-021-03664-8 |