PF3D7_0315300

Genome location: Pf3D7_03_v3:623,446..630,360(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	possibly expressed	0.21	0.89
Schizont	possibly expressed	0.37	0.80
Gametocyte	not expressed	0.74	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0315300

Resistome Missense Mutations: Y485D

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 5 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.563 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0413000)

Relative Growth Rate: 1.00 ± 0.19
Confidence: 4.70

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0413000)

Modification: Disrupted | RMgm-1899

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97276

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=6.80) with 7DI7 (Global RMSD=42.64)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533582

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	46	21	73
disruptive	36	160	93	244
missense	30	149	85	214

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	87	45	94
disruptive	92	369	193	384
missense	54	297	159	281

PlasmoDB Total SNPs: 328

Non-coding: 190 | Synonymous: 78 | Nonsynonymous: 60 | Stop Codon: 0

Protein Information

Protein Length: 1767 | Molecular Weight (kDa): 217.255

UniProt ID(s): O97276

PDB ID(s): None

Isoelectric Point: 9.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095