About Gene List

PF3D7_0315400

Genome location: Pf3D7_03_v3:630,342..631,821(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.11 0.94
Trophozoite expressed 1.00 0.49
Schizont expressed 0.32 0.82
Gametocyte expressed 0.47 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0315400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.044 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0413200)

  • Relative Growth Rate: 0.54 ± 0.15
  • Confidence: 5.14

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0413200)

Modification: Disrupted | RMgm-1900

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97269

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532570

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 10 3 15
disruptive 10 29 13 27
missense 4 22 13 20

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 16 9 18
disruptive 18 63 25 75
missense 8 43 21 45

PlasmoDB Total SNPs: 51

Non-coding: 24 | Synonymous: 15 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 256 | Molecular Weight (kDa): 30.522

UniProt ID(s): O97269

PDB ID(s): None

Isoelectric Point: 7.96

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895