About Gene List

PF3D7_0315600

Genome location: Pf3D7_03_v3:635,060..638,072(+)

Genome classification: Core

Function and Localization

Product Description: male development protein MD3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.02 0.99
Trophozoite expressed 0.07 0.96
Schizont expressed 0.02 0.99
Gametocyte expressed 0.43 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0315600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.353 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0413400)

Modification: Disrupted | RMgm-5079

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97271

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533366

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 21 16 28
disruptive 12 69 39 70
missense 10 61 34 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 52 20 19
disruptive 29 115 49 103
missense 24 102 38 73

PlasmoDB Total SNPs: 143

Non-coding: 114 | Synonymous: 15 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 485 | Molecular Weight (kDa): 57.072

UniProt ID(s): O97271

PDB ID(s): None

Isoelectric Point: 10.15

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596