About Gene List

PF3D7_0315700

Genome location: Pf3D7_03_v3:638,283..641,306(+)

Genome classification: Core

Function and Localization

Product Description: STONES protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 12

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite possibly expressed 0.05 0.97
Schizont possibly expressed 0.02 0.99
Gametocyte expressed 0.34 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0315700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.319 | #Insertions: 9

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0413500)

  • Relative Growth Rate: 0.97 ± 0.08
  • Confidence: 6.55

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0413500)

Modification: Tagged | RMgm-5350

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97272

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532662

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 19 28 48
disruptive 12 36 35 66
missense 8 32 32 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 61 38 50
disruptive 30 95 54 159
missense 15 66 49 118

PlasmoDB Total SNPs: 54

Non-coding: 20 | Synonymous: 25 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 936 | Molecular Weight (kDa): 112.218

UniProt ID(s): O97272

PDB ID(s): None

Isoelectric Point: 9.53

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095