Product Description: STONES protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.05 | 0.98 |
Trophozoite | possibly expressed | 0.05 | 0.97 |
Schizont | possibly expressed | 0.02 | 0.99 |
Gametocyte | expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0315700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.319 | #Insertions: 9
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0413500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0413500)
Modification: Tagged | RMgm-5350
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97272
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 19 | 28 | 48 |
disruptive | 12 | 36 | 35 | 66 |
missense | 8 | 32 | 32 | 58 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 61 | 38 | 50 |
disruptive | 30 | 95 | 54 | 159 |
missense | 15 | 66 | 49 | 118 |
PlasmoDB Total SNPs: 54
Non-coding: 20 | Synonymous: 25 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 936 | Molecular Weight (kDa): 112.218
UniProt ID(s): O97272
PDB ID(s): None
Isoelectric Point: 9.53
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |