PF3D7_0315800

Genome location: Pf3D7_03_v3:641,255..643,023(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0005634	nucleus
Function	GO:0061630	ubiquitin protein ligase activity
Process	GO:0016567	protein ubiquitination
Process	GO:0030155	regulation of cell adhesion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.43	0.79
Trophozoite	expressed	0.38	0.77
Schizont	expressed	0.10	0.93
Gametocyte	possibly expressed	0.31	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0315800

Resistome Missense Mutations: S328Y

Resistome Compounds with Missense Mutations: MMV982556

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: 0.28 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97273

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125339

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	13	9	18
disruptive	16	43	31	76
missense	8	39	24	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	35	14	27
disruptive	25	112	59	109
missense	13	85	47	75

PlasmoDB Total SNPs: 83

Non-coding: 59 | Synonymous: 7 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 365 | Molecular Weight (kDa): 41.983

UniProt ID(s): O97273

PDB ID(s): None

Isoelectric Point: 7.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013087	Zinc finger C2H2-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
InterPro	IPR040383	E3 ubiquitin-protein ligase HAKAI/CBLL2
PFam	N/A	N/A
Superfamily	SSF57850	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108