About Gene List

PF3D7_0315900

Genome location: Pf3D7_03_v3:644,186..645,268(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MTYVYYLFFLLICILLNKQWILLNKA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite not expressed 0.01 1.00
Schizont not expressed 0.01 0.99
Gametocyte not expressed 0.08 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0315900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.175 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97274

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532494

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 13 5 20
disruptive 1 9 8 21
missense 1 9 8 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 21 14 15
disruptive 8 25 18 46
missense 2 23 16 41

PlasmoDB Total SNPs: 39

Non-coding: 31 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 277 | Molecular Weight (kDa): 33.305

UniProt ID(s): O97274

PDB ID(s): None

Isoelectric Point: 6.76

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095