About Gene List

PF3D7_0316000 (MA)

Genome location: Pf3D7_03_v3:645,489..647,748(-)

Genome classification: Core

Function and Localization

Product Description: microneme associated antigen

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0020009 microneme
Component GO:0005739 mitochondrion
Function GO:0046812 host cell surface binding
Process GO:0098609 cell-cell adhesion
Process GO:0044409 entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.49 0.84
Trophozoite possibly expressed 0.12 0.92
Schizont expressed 0.36 0.86
Gametocyte expressed 0.37 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0316000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.162 | MFS: -3.384 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0413800)

Modification: Mutated | RMgm-4734

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77394

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532957

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 6 5 16
disruptive 12 21 13 36
missense 12 20 13 32

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 17 14 18
disruptive 23 59 32 60
missense 18 44 28 42

PlasmoDB Total SNPs: 121

Non-coding: 101 | Synonymous: 14 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 307 | Molecular Weight (kDa): 37.128

UniProt ID(s): O77394

PDB ID(s): None

Isoelectric Point: 9.85

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
24058628 Identification and characterization of a novel Plasmodium falciparum adhesininvolved in erythrocyte invasion. Hans N, Singh S, ..., Chauhan VS 10.1371/journal.pone.0074790
26292257 Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. Aguiar JC, Bolton J, ..., Richie TL 10.1371/journal.pone.0136109
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21