About Gene List

PF3D7_0316100

Genome location: Pf3D7_03_v3:647,361..649,671(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein L27, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005762 mitochondrial large ribosomal subunit
Component GO:0005739 mitochondrion
Function GO:0003735 structural constituent of ribosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.24 0.90
Trophozoite expressed 0.23 0.85
Schizont expressed 0.12 0.94
Gametocyte expressed 0.58 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0316100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -3.139 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0413900)

  • Relative Growth Rate: 0.11 ± 0.07
  • Confidence: 6.71

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NDU6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_141916

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 12 14 20
disruptive 4 15 14 31
missense 3 14 14 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 29 8 25
disruptive 7 41 35 64
missense 6 36 33 46

PlasmoDB Total SNPs: 232

Non-coding: 211 | Synonymous: 4 | Nonsynonymous: 15 | Stop Codon: 2

Protein Information

Protein Length: 298 | Molecular Weight (kDa): 35.411

UniProt ID(s): Q9NDU6

PDB ID(s): None

Isoelectric Point: 10.46

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001684 Ribosomal protein L27
PFam PF01016 Ribosomal protein L27
Superfamily SSF110324 N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21