About Gene List

PF3D7_0316200

Genome location: Pf3D7_03_v3:649,743..657,416(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.14 0.93
Trophozoite expressed 1.02 0.50
Schizont expressed 0.76 0.62
Gametocyte expressed 1.05 0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0316200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.923 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77393

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533069

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 25 86 55 121
disruptive 127 247 135 337
missense 80 188 112 276

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 46 172 85 131
disruptive 197 561 252 585
missense 109 397 201 405

PlasmoDB Total SNPs: 326

Non-coding: 65 | Synonymous: 159 | Nonsynonymous: 102 | Stop Codon: 0

Protein Information

Protein Length: 2423 | Molecular Weight (kDa): 293.713

UniProt ID(s): O77393

PDB ID(s): None

Isoelectric Point: 9.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095