Product Description: inorganic pyrophosphatase, putative, inorganic pyrophosphatase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.1.1 (Inorganic diphosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005829 | cytosol |
| Function | GO:0004427 | inorganic diphosphatase activity |
| Function | GO:0000287 | magnesium ion binding |
| Process | GO:0071344 | diphosphate metabolic process |
| Process | GO:0006796 | phosphate-containing compound metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0316300.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.971 | MFS: -2.948 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H477
"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.02) with 5CUX (Global RMSD=2.20)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100346
Most Similar Human Ortholog: Q5SQT6
TM-align score: 0.92 | RMSD: 1.50
Seq Identity: 0.38 | Length: 173 / 380
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138777 | inorganic pyrophosphatase 2 |
| ENSG00000180817 | inorganic pyrophosphatase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 17 | 20 | 29 |
| disruptive | 5 | 25 | 14 | 47 |
| missense | 5 | 24 | 13 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 45 | 28 | 21 |
| disruptive | 13 | 57 | 45 | 119 |
| missense | 10 | 45 | 37 | 80 |
PlasmoDB Total SNPs: 106
Non-coding: 85 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 2
Protein Length: 380 | Molecular Weight (kDa): 45.232
UniProt ID(s): O77392
PDB ID(s): 5WRU
Isoelectric Point: 6.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008162 | Inorganic pyrophosphatase |
| InterPro | IPR036649 | Inorganic pyrophosphatase superfamily |
| PFam | PF00719 | Inorganic pyrophosphatase |
| Superfamily | SSF50324 | Inorganic pyrophosphatase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 37690059 | Analog-sensitive Cdk1 as a tool to study mitotic exit: protein phosphatase 1 isrequired downstream from Cdk1 inactivation in budding yeast | Keaton JM, Workman BG, Xie L, Paulson JR | 10.1007/s10577-023-09736-6 |
| 36937295 | Structural analysis of the housecleaning nucleoside triphosphatepyrophosphohydrolase MazG from Mycobacterium tuberculosis | Wang S, Gao B, ..., Li J | 10.3389/fmicb.2023.1137279 |
| 37371733 | Serine/Threonine Protein Phosphatases 1 and 2A in Lung Endothelial BarrierRegulation | Patil RS, Kovacs-Kasa A, ..., Verin AD | 10.3390/biomedicines11061638 |