About Gene List

PF3D7_0316400

Genome location: Pf3D7_03_v3:662,081..665,690(-)

Genome classification: Core

Function and Localization

Product Description: CS domain-containing protein, putative

SignalP Peptide: MNTLYIFIGIIVIILCSRFCNN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite possibly expressed 0.60 0.66
Schizont possibly expressed 0.28 0.82
Gametocyte not expressed 0.69 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0316400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.381 | MFS: -2.514 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0414200)

  • Relative Growth Rate: 0.07 ± 0.05
  • Confidence: 7.58

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77391

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149549

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 39 22 46
disruptive 33 113 59 164
missense 20 82 49 130

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 77 30 72
disruptive 61 238 117 193
missense 33 163 95 144

PlasmoDB Total SNPs: 199

Non-coding: 78 | Synonymous: 76 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 1008 | Molecular Weight (kDa): 120.286

UniProt ID(s): O77391

PDB ID(s): None

Isoelectric Point: 8.33

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008978 HSP20-like chaperone
PFam N/A N/A
Superfamily SSF49764 HSP20-like chaperone

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596