PF3D7_0316700 (YOP1)

Genome location: Pf3D7_03_v3:673,290..676,084(+)

Genome classification: Core

Function and Localization

Product Description: protein YOP1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface
Component	GO:0005783	endoplasmic reticulum
Component	GO:0005634	nucleus
Process	GO:0007029	endoplasmic reticulum organization
Process	GO:0071786	endoplasmic reticulum tubular network organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.25	0.84
Schizont	expressed	0.32	0.78
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0316700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.11 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0414500)

Relative Growth Rate: 0.64 ± 0.07
Confidence: 6.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0414500)

Modification: Disrupted | RMgm-4832

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77388

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100903

Most Similar Human Ortholog: Q00765

TM-align score: 0.72 | RMSD: 2.69

Seq Identity: 0.38 | Length: 155 / 221

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000115255	receptor accessory protein 6
ENSG00000129625	receptor accessory protein 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	3	16
disruptive	3	6	5	15
missense	3	6	5	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	24	3	15
disruptive	5	27	11	52
missense	4	18	8	33

PlasmoDB Total SNPs: 246

Non-coding: 233 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 221 | Molecular Weight (kDa): 26.041

UniProt ID(s): O77388

PDB ID(s): None

Isoelectric Point: 10.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004345	TB2/DP1/HVA22-related protein
PFam	PF03134	TB2/DP1/HVA22-related protein
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
27128092	Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics.	Swearingen KE, Lindner SE, ..., Sinnis P	10.1371/journal.ppat.1005606
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596
32432369	A Plasmodium homolog of ER tubule-forming proteins is required for parasitevirulence.	Shi X, Hai L, ..., Bhanot P	10.1111/mmi.14526
22798490	Integrity and function of the Saccharomyces cerevisiae spindle pole body dependson connections between the membrane proteins Ndc1, Rtn1, and Yop1	Casey AK, Dawson TR, ..., Wente SR	10.1534/genetics.112.141465
34025654	Attenuated T Cell Responses Are Associated With the Blockade of Cerebral MalariaDevelopment by YOP1-Deficient Plasmodium berghei ANKA	Hai L, Shi X, Wang Q	10.3389/fimmu.2021.642585
21502358	A 3D analysis of yeast ER structure reveals how ER domains are organized bymembrane curvature	West M, Zurek N, Hoenger A, Voeltz GK	10.1083/jcb.201011039