Product Description: 40S ribosomal protein S15A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.27 | 0.45 |
| Trophozoite | expressed | 1.32 | 0.37 |
| Schizont | expressed | 0.29 | 0.82 |
| Gametocyte | expressed | 0.89 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0316800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.133 | MFS: -3.103 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0616000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77395
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100322
Most Similar Human Ortholog: P62244
TM-align score: 0.99 | RMSD: 0.34
Seq Identity: 0.73 | Length: 130 / 130
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134419 | ribosomal protein S15a |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 6 | 8 |
| disruptive | 0 | 0 | 1 | 7 |
| missense | 0 | 0 | 1 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 16 | 5 | 7 |
| disruptive | 0 | 8 | 13 | 26 |
| missense | 0 | 4 | 11 | 19 |
PlasmoDB Total SNPs: 120
Non-coding: 118 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 130 | Molecular Weight (kDa): 14.874
UniProt ID(s): O77395
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000630 | Ribosomal protein S8 |
| InterPro | IPR035987 | Ribosomal protein S8 superfamily |
| PFam | PF00410 | Ribosomal protein S8 |
| Superfamily | SSF56047 | Ribosomal protein S8 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |