Product Description: nucleoporin NUP335, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0003700 | DNA-binding transcription factor activity |
| Function | GO:0005515 | protein binding |
| Function | GO:0043565 | sequence-specific DNA binding |
| Process | GO:0045893 | positive regulation of transcription, DNA-templated |
| Process | GO:0016540 | protein autoprocessing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.48 | 0.17 |
| Trophozoite | expressed | 2.26 | 0.14 |
| Schizont | expressed | 2.56 | 0.10 |
| Gametocyte | expressed | 1.80 | 0.24 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0317300
Resistome Missense Mutations: D3195E
Resistome Compounds with Missense Mutations: AN13762, AN13956
Resistome # Samples with Disruptive Mutations: 8 (3 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.118 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0807900)
Modification: Tagged | RMgm-5246
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 45 | 130 | 91 | 185 |
| disruptive | 345 | 601 | 269 | 644 |
| missense | 138 | 346 | 185 | 430 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 68 | 247 | 112 | 199 |
| disruptive | 518 | 1080 | 443 | 861 |
| missense | 206 | 664 | 301 | 503 |
PlasmoDB Total SNPs: 900
Non-coding: 172 | Synonymous: 315 | Nonsynonymous: 407 | Stop Codon: 6
Protein Length: 3394 | Molecular Weight (kDa): 402.952
UniProt ID(s): O77384
PDB ID(s): None
Isoelectric Point: 4.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34268135 | The Transcription Factor PfAP2-O Influences Virulence Gene Transcription andSexual Development in Plasmodium falciparum. | Cubillos EFG, Prata IO, ..., Wunderlich G | https://pubmed.ncbi.nlm.nih.gov/34268135/ |
| 36040030 | TurboID Identification of Evolutionarily Divergent Components of the Nuclear PoreComplex in the Malaria Model Plasmodium berghei. | Ambekar SV, Beck JR, Mair GR | 10.1128/mbio.01815-22 |