Product Description: kinesin-5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005871 | kinesin complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0008017 | microtubule binding |
| Function | GO:0003777 | microtubule motor activity |
| Function | GO:0008574 | plus-end-directed microtubule motor activity |
| Process | GO:0007018 | microtubule-based movement |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.35 | 0.83 |
| Trophozoite | expressed | 0.83 | 0.56 |
| Schizont | expressed | 0.78 | 0.59 |
| Gametocyte | expressed | 0.66 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0317500
Resistome Missense Mutations: G829E
Resistome Compounds with Missense Mutations: BRD9685, Cipargamin/KAE609/NITD609
Resistome # Samples with Disruptive Mutations: 16 (4 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.249 | #Insertions: 10
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0807700)
Modification: Tagged | RMgm-5024
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77382
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.04) with 2GM1 (Global RMSD=6.06)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P52732 | Kinesin-like protein KIF11 | Homo sapiens | OrthoDB | TritylcysteineS-Trityl-L-Cysteine (STLC) Analogue, 3S-Trityl-L-Cysteine (STLC) Analogue, 4S-Trityl-L-Cysteine (STLC) Analogue, 5... |
Ortholog Group (OrthoMCL): OG6_102884
Most Similar Human Ortholog: A0A7I2V3V3
TM-align score: 0.69 | RMSD: 3.72
Seq Identity: 0.42 | Length: 406 / 1619
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138160 | kinesin family member 11 |
Protein Length: 1619 | Molecular Weight (kDa): 191.785
UniProt ID(s): O77382
PDB ID(s): 7NB8
Isoelectric Point: 6.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001752 | Kinesin motor domain |
| InterPro | IPR019821 | Kinesin motor domain, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR027640 | Kinesin-like protein |
| PFam | PF00225 | Kinesin motor domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 79 | 35 | 92 |
| disruptive | 81 | 197 | 89 | 205 |
| missense | 53 | 127 | 76 | 160 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 48 | 146 | 55 | 110 |
| disruptive | 147 | 355 | 164 | 373 |
| missense | 88 | 235 | 132 | 246 |
PlasmoDB Total SNPs: 318
Non-coding: 99 | Synonymous: 106 | Nonsynonymous: 113 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24737313 | Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5. | Liu L, Richard J, Kim S, Wojcik EJ | 10.1074/jbc.M114.551408 |
| 34375637 | Cryo-EM structure of a microtubule-bound parasite kinesin motor and implicationsfor its mechanism and inhibition. | Cook AD, Roberts AJ, ..., Moores CA | 10.1016/j.jbc.2021.101063 |
| 38265238 | Requirement of microtubules for secretion of a micronemal protein CpTSP4 in theinvasive stage of the apicomplexan Cryptosporidium parvum | Wang D, Jiang P, ..., Zhu G | 10.1128/mbio.03158-23 |