Product Description: 40S ribosomal protein S11, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.46 | 0.78 |
| Trophozoite | expressed | 0.72 | 0.61 |
| Schizont | possibly expressed | 0.10 | 0.93 |
| Gametocyte | not expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0317600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.987 | MFS: -2.687 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77381
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100208
Most Similar Human Ortholog: M0R1H5
TM-align score: 0.94 | RMSD: 0.80
Seq Identity: 0.70 | Length: 78 / 161
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000142534 | ribosomal protein S11 |
| ENSG00000239789 | mitochondrial ribosomal protein S17 |
| ENSG00000249773 | novel zinc finger protein 713 (ZNF713) and mitochondrial ribosomal protein S17 (MRPS17) protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 8 | 17 |
| disruptive | 1 | 3 | 3 | 4 |
| missense | 1 | 3 | 3 | 3 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 19 | 14 | 15 |
| disruptive | 1 | 12 | 6 | 38 |
| missense | 1 | 8 | 6 | 27 |
PlasmoDB Total SNPs: 112
Non-coding: 108 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 161 | Molecular Weight (kDa): 18.76
UniProt ID(s): O77381
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000266 | Ribosomal protein S17/S11 |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR019979 | Ribosomal protein S17, conserved site |
| InterPro | IPR028333 | Ribosomal protein S17, archaeal/eukaryotic |
| InterPro | IPR032440 | 40S ribosomal protein S11, N-terminal |
| PFam | PF00366 | Ribosomal protein S17/S11 |
| PFam | PF16205 | 40S ribosomal protein S11, N-terminal |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |