Product Description: 26S proteasome non-ATPase regulatory subunit 9, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0005838 | proteasome regulatory particle |
| Process | GO:0070682 | proteasome regulatory particle assembly |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.38 | 0.82 |
| Trophozoite | expressed | 1.20 | 0.42 |
| Schizont | expressed | 0.28 | 0.84 |
| Gametocyte | possibly expressed | 0.34 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0317800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.987 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77379
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102356
Most Similar Human Ortholog: F5H7X1
TM-align score: 0.74 | RMSD: 1.06
Seq Identity: 0.38 | Length: 68 / 225
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000110801 | proteasome 26S subunit, non-ATPase 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 14 | 5 | 15 |
| disruptive | 6 | 24 | 14 | 34 |
| missense | 6 | 24 | 14 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 20 | 6 | 17 |
| disruptive | 11 | 50 | 20 | 36 |
| missense | 9 | 47 | 19 | 34 |
PlasmoDB Total SNPs: 101
Non-coding: 87 | Synonymous: 5 | Nonsynonymous: 8 | Stop Codon: 1
Protein Length: 225 | Molecular Weight (kDa): 26.466
UniProt ID(s): O77379
PDB ID(s): None
Isoelectric Point: 6.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR035269 | 26S Proteasome non-ATPase regulatory subunit 9 |
| InterPro | IPR036034 | PDZ superfamily |
| InterPro | IPR040815 | Nas2, N-terminal |
| PFam | PF18265 | Nas2, N-terminal |
| Superfamily | SSF50156 | PDZ superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 26639022 | Characterization of the 26S proteasome network in Plasmodium falciparum. | Wang L, Delahunty C, ..., Becker K | 10.1038/srep17818 |