About Gene List

PF3D7_0317900

Genome location: Pf3D7_03_v3:739,193..742,054(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.05 0.98
Trophozoite expressed 0.20 0.87
Schizont possibly expressed 0.02 0.98
Gametocyte not expressed 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0317900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.294 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0807300)

  • Relative Growth Rate: 0.26 ± 0.13
  • Confidence: 5.53

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0807300)

Modification: Disrupted | RMgm-2327

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H479

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139485

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 21 19 33
disruptive 11 50 29 70
missense 7 45 29 63

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 43 30 33
disruptive 22 88 51 121
missense 14 77 50 93

PlasmoDB Total SNPs: 129

Non-coding: 67 | Synonymous: 36 | Nonsynonymous: 22 | Stop Codon: 4

Protein Information

Protein Length: 689 | Molecular Weight (kDa): 83.081

UniProt ID(s): C0H479

PDB ID(s): None

Isoelectric Point: 8.84

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30204084 Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase Seidi A, Muellner-Wong LS, ..., van Dooren GG 10.7554/eLife.38131
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21