PF3D7_0318000

Genome location: Pf3D7_03_v3:742,191..742,799(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MQYLLLYILLSICSYNILS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.70	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0318000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.611 | MFS: -2.268 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0807200)

Modification: Disrupted | RMgm-2326

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77378

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533168

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	7	5	9
disruptive	3	28	16	34
missense	3	28	16	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	13	10	10
disruptive	7	53	20	45
missense	6	50	19	37

PlasmoDB Total SNPs: 10

Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 202 | Molecular Weight (kDa): 24.412

UniProt ID(s): O77378

PDB ID(s): None

Isoelectric Point: 8.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095