Product Description: stomatin-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.96 |
| Trophozoite | possibly expressed | 0.35 | 0.78 |
| Schizont | expressed | 0.02 | 0.98 |
| Gametocyte | not expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0318100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.926 | MFS: -2.4 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0807100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0807100)
Modification: Tagged | RMgm-4442
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77376
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101622
Most Similar Human Ortholog: Q9UJZ1
TM-align score: 0.70 | RMSD: 3.54
Seq Identity: 0.40 | Length: 283 / 374
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165283 | stomatin like 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 17 | 9 | 24 |
| disruptive | 1 | 21 | 10 | 25 |
| missense | 1 | 20 | 10 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 42 | 9 | 28 |
| disruptive | 8 | 50 | 21 | 56 |
| missense | 3 | 34 | 19 | 36 |
PlasmoDB Total SNPs: 77
Non-coding: 55 | Synonymous: 19 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 374 | Molecular Weight (kDa): 43.083
UniProt ID(s): O77376
PDB ID(s): None
Isoelectric Point: 9.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001107 | Band 7 domain |
| InterPro | IPR001972 | Stomatin/HflK/HflC family |
| InterPro | IPR032435 | Band 7, C-terminal extension |
| InterPro | IPR036013 | Band 7/SPFH domain superfamily |
| PFam | PF01145 | Band 7 domain |
| PFam | PF16200 | Band 7, C-terminal extension |
| Superfamily | SSF117892 | Band 7/SPFH domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29669282 | An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial MembranePotential. | Matz JM, Goosmann C, Matuschewski K, Kooij TWA | 10.1016/j.celrep.2018.03.088 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |