PF3D7_0318400

Genome location: Pf3D7_03_v3:761,693..765,439(-)

Genome classification: Core

Function and Localization

Product Description: coiled-coil domain-containing protein CCDC148/CCDC112, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.05	0.96
Gametocyte	not expressed	0.55	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0318400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.993 | MFS: -2.155 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77373

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=3.62) with 4I8V (Global RMSD=20.93)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532329

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	25	17	36
disruptive	17	77	34	105
missense	17	76	34	93

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	50	26	36
disruptive	42	155	83	145
missense	36	126	68	117

PlasmoDB Total SNPs: 279

Non-coding: 218 | Synonymous: 43 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 591 | Molecular Weight (kDa): 70.84

UniProt ID(s): O77373

PDB ID(s): None

Isoelectric Point: 5.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039902	Coiled-coil domain-containing protein CCDC148/CCDC112
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095