PF3D7_0318500

Genome location: Pf3D7_03_v3:766,814..782,795(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0318500

Resistome Missense Mutations: D2102N, L2540F

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609, MMV019662

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 3 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.816 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0806700)

Modification: Disrupted | RMgm-2322

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533557

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 569

Non-coding: 67 | Synonymous: 296 | Nonsynonymous: 205 | Stop Codon: 1

Protein Information

Protein Length: 4981 | Molecular Weight (kDa): 593.259

UniProt ID(s): O77372

PDB ID(s): None

Isoelectric Point: 9.31

Protein Domain Annotations: