PF3D7_0318900

Genome location: Pf3D7_03_v3:791,312..794,096(-)

Genome classification: Core

Function and Localization

Product Description: PAT complex subunit CCDC47, putative

SignalP Peptide: MQKFISVIFLFIIYLSFHLIYT

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005783	endoplasmic reticulum
Function	GO:0003723	RNA binding
Function	GO:0005509	calcium ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.54	0.75
Trophozoite	expressed	1.07	0.45
Schizont	expressed	0.60	0.65
Gametocyte	expressed	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0318900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.902 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0806400)

Relative Growth Rate: 1.01 ± 0.13
Confidence: 5.46

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0806400)

Modification: Disrupted | RMgm-2319

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77369

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103006

Most Similar Human Ortholog: J3KRX4

TM-align score: 0.80 | RMSD: 0.35

Seq Identity: 0.00 | Length: 19 / 440

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000108588	coiled-coil domain containing 47

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	16	15	29
disruptive	9	52	38	60
missense	6	48	35	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	39	15	31
disruptive	27	132	63	95
missense	13	107	47	66

PlasmoDB Total SNPs: 112

Non-coding: 83 | Synonymous: 13 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 440 | Molecular Weight (kDa): 53.115

UniProt ID(s): O77369, Q689B8

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012879	Protein of unknown function DUF1682
PFam	PF07946	Protein of unknown function DUF1682
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
33906926	Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH	Sinha A, Baumgarten S, ..., Scherf A	10.1128/mBio.00661-21