Product Description: CCR4 domain-containing protein 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005634 | nucleus |
| Function | GO:0000175 | 3'-5'-exoribonuclease activity |
| Function | GO:0004518 | nuclease activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.61 | 0.72 |
| Trophozoite | expressed | 1.00 | 0.49 |
| Schizont | expressed | 0.23 | 0.86 |
| Gametocyte | expressed | 0.62 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0319200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.786 | #Insertions: 5
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0806100)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0809300)
Modification: Disrupted | RMgm-4587
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77366
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=6.00) with 2PML (Global RMSD=18.98)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q6L8Q7 | 2',5'-phosphodiesterase 12 | OrthoDB | CHEMBL4556129CHEMBL4556129 |
Ortholog Group (OrthoMCL): OG6_104860
Most Similar Human Ortholog: Q6L8Q7
TM-align score: 0.78 | RMSD: 4.40
Seq Identity: 0.18 | Length: 566 / 906
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000174840 | phosphodiesterase 12 |
Protein Length: 906 | Molecular Weight (kDa): 108.306
UniProt ID(s): O77366
PDB ID(s): None
Isoelectric Point: 9.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005135 | Endonuclease/exonuclease/phosphatase |
| InterPro | IPR036691 | Endonuclease/exonuclease/phosphatase superfamily |
| PFam | PF03372 | Endonuclease/exonuclease/phosphatase |
| Superfamily | SSF56219 | Endonuclease/exonuclease/phosphatase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 27 | 14 | 38 |
| disruptive | 29 | 97 | 53 | 147 |
| missense | 23 | 95 | 53 | 137 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 55 | 26 | 50 |
| disruptive | 51 | 206 | 124 | 223 |
| missense | 35 | 181 | 108 | 184 |
PlasmoDB Total SNPs: 99
Non-coding: 54 | Synonymous: 26 | Nonsynonymous: 18 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29914511 | Identification and characterization of DNA endonucleases in Plasmodium falciparum3D7 clone. | Jiang N, Tu Z, ..., Chen Q | 10.1186/s12936-018-2388-0 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |