Product Description: kinesin-8X
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005871 | kinesin complex |
| Component | GO:0005874 | microtubule |
| Component | GO:0072686 | mitotic spindle |
| Component | GO:0005634 | nucleus |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0008017 | microtubule binding |
| Function | GO:0003777 | microtubule motor activity |
| Function | GO:0008574 | plus-end-directed microtubule motor activity |
| Process | GO:0007019 | microtubule depolymerization |
| Process | GO:0007018 | microtubule-based movement |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 1.08 | 0.50 |
| Schizont | expressed | 0.54 | 0.72 |
| Gametocyte | expressed | 0.86 | 0.56 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0319400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.037 | #Insertions: 10
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0805900)
Modification: Tagged | RMgm-5023
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97277
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.02) with 6TRL (Global RMSD=4.74)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q8NI77 | Kinesin-like protein KIF18A | OrthoDB | US11236069, Example 1US11236069, Example 1-1US11236069, Example 1-2US11236069, Example 1-3... |
Protein Length: 1363 | Molecular Weight (kDa): 157.396
UniProt ID(s): O97277
PDB ID(s): None
Isoelectric Point: 9.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001752 | Kinesin motor domain |
| InterPro | IPR011004 | Trimeric LpxA-like superfamily |
| InterPro | IPR018357 | Hexapeptide transferase, conserved site |
| InterPro | IPR019821 | Kinesin motor domain, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR027640 | Kinesin-like protein |
| PFam | PF00225 | Kinesin motor domain |
| Superfamily | SSF51161 | Trimeric LpxA-like superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 70 | 24 | 74 |
| disruptive | 60 | 154 | 75 | 169 |
| missense | 29 | 97 | 57 | 126 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 26 | 127 | 41 | 86 |
| disruptive | 118 | 293 | 160 | 358 |
| missense | 50 | 195 | 112 | 205 |
PlasmoDB Total SNPs: 362
Non-coding: 132 | Synonymous: 119 | Nonsynonymous: 111 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31600347 | Plasmodium kinesin-8X associates with mitotic spindles and is essential foroocyst development during parasite proliferation and transmission. | Zeeshan M, Shilliday F, ..., Tewari R | 10.1371/journal.ppat.1008048 |