Product Description: RNA-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0071011 | precatalytic spliceosome |
| Function | GO:0003723 | RNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.58 | 0.73 |
| Trophozoite | expressed | 0.86 | 0.54 |
| Schizont | expressed | 0.15 | 0.91 |
| Gametocyte | expressed | 0.64 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0319500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.869 | MFS: -2.193 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0805800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97318
"Best" AlphaFill ligand hit: M2M (1-methoxy-2-(2-methoxyethoxy)ethane, Local RMSD=0.51) with 4ED5 (Global RMSD=5.80)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102431
Most Similar Human Ortholog: Q5JY83
TM-align score: 0.84 | RMSD: 1.78
Seq Identity: 0.46 | Length: 57 / 309
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134597 | RNA binding motif protein X-linked 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 17 | 5 | 16 |
| disruptive | 17 | 45 | 34 | 66 |
| missense | 11 | 29 | 26 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 25 | 9 | 23 |
| disruptive | 30 | 104 | 46 | 92 |
| missense | 15 | 64 | 39 | 52 |
PlasmoDB Total SNPs: 160
Non-coding: 101 | Synonymous: 14 | Nonsynonymous: 45 | Stop Codon: 0
Protein Length: 309 | Molecular Weight (kDa): 36.611
UniProt ID(s): O97318
PDB ID(s): None
Isoelectric Point: 7.38
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |