Genome location: Pf3D7_03_v3:817,542..819,496(+)
Genome classification: Core
Product Description: elongation factor 1-delta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005853 | eukaryotic translation elongation factor 1 complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Function | GO:0003746 | translation elongation factor activity |
| Process | GO:0006414 | translational elongation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.56 | 0.74 |
| Trophozoite | expressed | 0.80 | 0.57 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0319600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.155 | MFS: -2.75 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0814200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97319
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101695
Most Similar Human Ortholog: P24534
TM-align score: 0.63 | RMSD: 3.06
Seq Identity: 0.33 | Length: 117 / 156
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000114942 | eukaryotic translation elongation factor 1 beta 2 |
| ENSG00000283391 | eukaryotic translation elongation factor 1 beta 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 2 | 10 |
| disruptive | 3 | 9 | 9 | 28 |
| missense | 3 | 9 | 7 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 8 | 11 |
| disruptive | 4 | 25 | 25 | 35 |
| missense | 4 | 22 | 20 | 26 |
PlasmoDB Total SNPs: 148
Non-coding: 141 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 156 | Molecular Weight (kDa): 17.706
UniProt ID(s): O97319
PDB ID(s): None
Isoelectric Point: 4.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR014038 | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain |
| InterPro | IPR036219 | Translation elongation factor eEF-1beta-like superfamily |
| PFam | PF00736 | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain |
| Superfamily | SSF54984 | Translation elongation factor eEF-1beta-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17307963 | Purification of components of the translation elongation factor complex ofPlasmodium falciparum by tandem affinity purification. | Takebe S, Witola WH, ..., Ben Mamoun C | 10.1128/EC.00376-06 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 38199565 | Methylation of elongation factor 1A by yeast Efm4 or human eEF1A-KMT2 involves abeta-hairpin recognition motif and crosstalks with phosphorylation | Hamey JJ, Nguyen A, ..., Wilkins MR | 10.1016/j.jbc.2024.105639 |
| 37861337 | Eukaryotic translation elongation factor 1 alpha (eEF1A) inhibits Sinipercachuatsi rhabdovirus (SCRV) infection through two distinct mechanisms | Meng X-Y, Jiang Q-Q, ..., Ke F | 10.1128/jvi.01226-23 |