Product Description: ABC transporter I family member 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 13
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043231 | intracellular membrane-bounded organelle |
| Component | GO:0016020 | membrane |
| Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Function | GO:0005319 | lipid transporter activity |
| Process | GO:0006869 | lipid transport |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 2.06 | 0.24 |
| Trophozoite | expressed | 0.97 | 0.54 |
| Schizont | possibly expressed | 0.64 | 0.71 |
| Gametocyte | expressed | 1.23 | 0.41 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0319700
Resistome Missense Mutations: L690I, Y2079C, R2180G, R2180P, H2181L
Resistome Compounds with Missense Mutations: MMV020746, MMV407834, MMV665939
Resistome # Samples with Disruptive Mutations: 7 (7 missense, 5 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.547 | MFS: -3.154 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1218800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1218800)
Modification: Tagged | RMgm-1404
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P41233 | Phospholipid-transporting ATPase ABCA1 | Mus musculus | OrthoDB | CHEMBL1632440CHEMBL1630186CHEMBL1630191CHEMBL1630192... |
Ortholog Group (OrthoMCL): OG6_100045
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3133
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000064687 | ATP binding cassette subfamily A member 7 |
| ENSG00000107331 | ATP binding cassette subfamily A member 2 |
| ENSG00000141338 | ATP binding cassette subfamily A member 8 |
| ENSG00000144452 | ATP binding cassette subfamily A member 12 |
| ENSG00000154258 | ATP binding cassette subfamily A member 9 |
| ENSG00000154262 | ATP binding cassette subfamily A member 6 |
| ENSG00000154263 | ATP binding cassette subfamily A member 10 |
| ENSG00000154265 | ATP binding cassette subfamily A member 5 |
| ENSG00000165029 | ATP binding cassette subfamily A member 1 |
| ENSG00000167972 | ATP binding cassette subfamily A member 3 |
| ENSG00000179869 | ATP binding cassette subfamily A member 13 |
| ENSG00000198691 | ATP binding cassette subfamily A member 4 |
Protein Length: 3133 | Molecular Weight (kDa): 375.808
UniProt ID(s): O97278
PDB ID(s): None
Isoelectric Point: 8.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR026082 | ABC transporter A |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00005 | ABC transporter-like |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 141 | 96 | 187 |
| disruptive | 88 | 368 | 195 | 461 |
| missense | 59 | 315 | 179 | 407 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 285 | 134 | 214 |
| disruptive | 171 | 734 | 312 | 710 |
| missense | 102 | 597 | 275 | 536 |
PlasmoDB Total SNPs: 329
Non-coding: 114 | Synonymous: 104 | Nonsynonymous: 108 | Stop Codon: 3
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 26796412 | Functional profiles of orphan membrane transporters in the life cycle of themalaria parasite. | Kenthirapalan S, Waters AP, Matuschewski K, Kooij TW | 10.1038/ncomms10519 |
| 34233174 | The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependentpleiotropic antimalarial drug resistance. | Murithi JM, Deni I, ..., Fidock DA | 10.1016/j.chembiol.2021.06.006 |
| 28971869 | ABCI3 Is a New Mitochondrial ABC Transporter from Leishmania major Involved inSusceptibility to Antimonials and Infectivity | Arcari T, Manzano JI, Gamarro F | 10.1128/AAC.01115-17 |
| 37398288 | Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness | Mok S, Yeo T, ..., Fidock DA | 10.1101/2023.06.02.543338 |
| 37939186 | Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness | Mok S, Yeo T, ..., Fidock DA | 10.1126/sciadv.adi2364 |