PF3D7_0319900

Genome location: Pf3D7_03_v3:833,687..835,444(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.21	0.89
Trophozoite	expressed	0.28	0.82
Schizont	expressed	0.11	0.92
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0319900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -2.675 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97279

"Best" AlphaFill ligand hit: OEY (ca-mn4-o6 cluster, Local RMSD=0.04) with 5WS6 (Global RMSD=17.66)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533769

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	17	10	21
disruptive	1	21	15	32
missense	1	18	15	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	31	16	19
disruptive	4	52	38	83
missense	2	43	33	56

PlasmoDB Total SNPs: 65

Non-coding: 53 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 314 | Molecular Weight (kDa): 36.143

UniProt ID(s): O97279

PDB ID(s): None

Isoelectric Point: 4.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095