Product Description: protein phosphatase inhibitor 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Function | GO:0004864 | protein phosphatase inhibitor activity |
| Function | GO:0004865 | protein serine/threonine phosphatase inhibitor activity |
| Process | GO:0043666 | regulation of phosphoprotein phosphatase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.95 |
| Trophozoite | not expressed | 0.85 | 0.54 |
| Schizont | possibly expressed | 0.29 | 0.82 |
| Gametocyte | not expressed | 1.10 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0320000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.513 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1218500)
Modification: Tagged | RMgm-5186
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H480
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_106897
Most Similar Human Ortholog: Q6NXS1
TM-align score: 0.37 | RMSD: 4.10
Seq Identity: 0.20 | Length: 73 / 144
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000184203 | protein phosphatase 1 regulatory inhibitor subunit 2 |
| ENSG00000231989 | PPP1R2 family member B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 1 | 7 |
| disruptive | 2 | 7 | 5 | 14 |
| missense | 2 | 6 | 5 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 3 | 13 |
| disruptive | 6 | 21 | 10 | 36 |
| missense | 4 | 13 | 10 | 28 |
PlasmoDB Total SNPs: 79
Non-coding: 75 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 144 | Molecular Weight (kDa): 16.701
UniProt ID(s): C0H480
PDB ID(s): None
Isoelectric Point: 4.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007062 | Protein phosphatase inhibitor 2 (IPP-2) |
| PFam | PF04979 | Protein phosphatase inhibitor 2 (IPP-2) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23837822 | Plasmodium falciparum encodes a conserved active inhibitor-2 for ProteinPhosphatase type 1: perspectives for novel anti-plasmodial therapy. | Freville A, Cailliau-Maggio K, ..., Khalife J | 10.1186/1741-7007-11-80 |
| 25132288 | Identification of a Plasmodium falciparum inhibitor-2 motif involved in thebinding and regulation activity of protein phosphatase type 1. | Freville A, Tellier G, ..., Landrieu I | 10.1111/febs.12960 |