Product Description: protein transport protein SEC22
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0000139 | Golgi membrane |
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0031201 | SNARE complex |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Function | GO:0005484 | SNAP receptor activity |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Process | GO:0048280 | vesicle fusion with Golgi apparatus |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.35 | 0.78 |
| Schizont | expressed | 0.22 | 0.85 |
| Gametocyte | expressed | 0.29 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0320100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.163 | MFS: -3.721 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1218400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97323
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101898
Most Similar Human Ortholog: O75396
TM-align score: 0.68 | RMSD: 2.21
Seq Identity: 0.32 | Length: 161 / 221
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000265808 | SEC22 homolog B, vesicle trafficking protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 9 | 5 | 14 |
| disruptive | 2 | 5 | 3 | 12 |
| missense | 1 | 5 | 2 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 17 | 7 | 12 |
| disruptive | 4 | 17 | 20 | 39 |
| missense | 1 | 9 | 18 | 24 |
PlasmoDB Total SNPs: 137
Non-coding: 117 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 221 | Molecular Weight (kDa): 25.934
PDB ID(s): None
Isoelectric Point: 9.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001388 | Synaptobrevin |
| InterPro | IPR010908 | Longin domain |
| InterPro | IPR011012 | Longin-like domain superfamily |
| PFam | PF00957 | Synaptobrevin |
| PFam | PF13774 | Longin domain |
| Superfamily | SSF58038 | Longin-like domain superfamily |
| Superfamily | SSF64356 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17240462 | Identification of Plasmodium falciparum family of SNAREs. | Ayong L, Pagnotti G, Tobon AB, Chakrabarti D | https://pubmed.ncbi.nlm.nih.gov/17240462/ |
| 19617396 | The longin domain regulates the steady-state dynamics of Sec22 in Plasmodiumfalciparum. | Ayong L, Raghavan A, ..., Chakrabarti D | 10.1128/EC.00092-09 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 30579794 | Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNAREprotein Sec22p in suppressing alpha-synuclein and Bax toxicity in yeast | Derf A, Sharma A, Bharate SB, Chaudhuri B | 10.1016/j.bmcl.2018.12.028 |
| 26450509 | Overexpression of native Saccharomyces cerevisiae ER-to-Golgi SNARE genesincreased heterologous cellulase secretion | Van Zyl JH, Den Haan R, Van Zyl WH | 10.1007/s00253-015-7022-2 |
| 26216899 | SNAREs support atlastin-mediated homotypic ER fusion in Saccharomyces cerevisiae | Lee M, Ko YJ, ..., Jun Y | 10.1083/jcb.201501043 |