PF3D7_0320200

Genome location: Pf3D7_03_v3:842,496..844,477(+)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: MKFSFFSVVICFVILAYS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	possibly expressed	0.08	0.95
Schizont	possibly expressed	0.04	0.98
Gametocyte	expressed	1.09	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0320200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.188 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1346300)

Relative Growth Rate: 1.02 ± 0.11
Confidence: 5.88

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1218300)

Modification: Tagged | RMgm-4860

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H481

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125525

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	22	6	35
disruptive	36	81	41	81
missense	14	43	28	57

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	44	16	36
disruptive	79	136	56	121
missense	30	80	40	76

PlasmoDB Total SNPs: 90

Non-coding: 24 | Synonymous: 34 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 583 | Molecular Weight (kDa): 68.929

UniProt ID(s): C0H481

PDB ID(s): None

Isoelectric Point: 7.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006387	CPW-WPC domain
PFam	PF09717	CPW-WPC domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095