About Gene List

PF3D7_0320400 (Cap380)

Genome location: Pf3D7_03_v3:848,247..857,504(-)

Genome classification: Core

Function and Localization

Product Description: oocyst capsule protein Cap380

SignalP Peptide: MHIFNIYNILFACLIGIVFS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite not expressed 0.04 0.98
Schizont not expressed 0.04 0.98
Gametocyte not expressed 0.08 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0320400

Resistome Missense Mutations: I123N

Resistome Compounds with Missense Mutations: BCH070

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.285 | #Insertions: 14

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1218100)

  • Relative Growth Rate: 0.90 ± 0.17
  • Confidence: 4.88

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1218100)

Modification: Disrupted | RMgm-3264

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532510

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 77 52 139
disruptive 92 137 78 248
missense 86 130 75 225

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 29 152 84 192
disruptive 130 247 161 377
missense 112 219 145 311

PlasmoDB Total SNPs: 182

Non-coding: 0 | Synonymous: 101 | Nonsynonymous: 81 | Stop Codon: 0

Protein Information

Protein Length: 3085 | Molecular Weight (kDa): 360.522

UniProt ID(s): O97283

PDB ID(s): None

Isoelectric Point: 6.6

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
29609625 PfCap380 as a marker for Plasmodium falciparum oocyst development in vivo and invitro. Itsara LS, Zhou Y, ..., Ghosh AK 10.1186/s12936-018-2277-6
37314965 Plasmodium GPI-anchored micronemal antigen is essential for parasite transmissionthrough the mosquito host Jennison C, Armstrong JM, ..., Vaughan AM 10.1111/mmi.15078
38097730 Plasmodium sporozoite excystation involves local breakdown of the oocyst capsule Saeed S, Tremp AZ, Dessens JT 10.1038/s41598-023-49442-1